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KMID : 0616120090400040365
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 4 p.365 ~ p.369
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HPLC Analysis of Caffeoylquinic Acids in the Extract of Cacalia firma and Peroxynitrite Scavenging Effect
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Park Hee-Juhn
Nugroho Agung
Lee Jin-Ha
Kim Jong-Dai
Kim Won-Bae
Lee Kang-Ro
Choi Jae-Sue
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Abstract
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Six caffeoylquinic acids of Cacalia firma (Komarov) Nakai (Compositae) leaves were identified using standard
compounds by HPLC. Each content of those compounds in dried weight was determined as follows: 3,4-di-O-caffeoylquinic acid (1.44±0.04 mg/g of dried weight), 3,5-di-O-caffeoyl-muce-quinic acid (2.47±0.12 mg/g), 3,5-di-O-caffeoylquinic acid (3.74±0.24 mg/g), 5-caffeoylquinic acid (chlorogenic acid, 5.20±0.09 mg/g), 3-caffeoylquinic acid (1.35±0.01 mg/g) and 3-Op-coumaroylquinic acid (3.84±0.25 mg/g). The total content of six caffeoylquinic acids in the plant material was calculated as 18.05±0.69 mg/g while the percentage of the six compounds in the MeOH extract was calculated as 30.85±1.18%. The IC50 value of the MeOH extract scavenging peroxynitrite (ONOO-) was shown as 3.22±0.57 μg/ml.
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KEYWORD
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Cacalia firma, Compositae, caffeoylquinic acid, peroxynitrite, HPLC
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